Coenzyme Q10
Test Description
Coenzyme Q10 (CoQ10) is an enzyme essential to mitochondrial ATP generation
and antioxidant function in lipid and mitochondrial membranes. According to the
American Association of Clinical Endocrinologists (2003), it has been found to have
beneficial effects for mitochondrial disorders, congestive heart failure (CHF), and
ischemia-reperfusion injury. In cases of insufficient CoQ10, electron transfer activity
of the mitochondria decreases. This results in an energy production inadequate
for cell operation. This can be especially stressful for tissues with very high energy
demand such as the heart muscle.
The role of CoQ10 in myopathy associated with statin use is also being studied.
Statins have been shown to create a CoQ10 deficiency, especially in the elderly,
since the enzyme typically decreases with age and in those with congestive heart failure.
The use of CoQ10 supplementation for statin-associated myopathy is starting to
gain support, since dietary sources of the enzyme are insufficient. Prophylactic therapy
may be considered with initiation of statin therapy. It may also be considered for
use with patients complaining of statin-associated myalgias who do not have laboratory
evidence of myositis or rhabdomyolysis, such as elevated creatine kinase levels.
ـــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــ
Normal Values
Therapeutic range for cardiovascular disease >2.5 mg/L
ـــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــ
Possible Meanings of Abnormal Values
Decreased
CoQ10 deficiency
ــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــ
Interventions/Implications
Pretest
• Explain to the patient the purpose of the test and the need for a blood sample to be drawn.
• No fasting is required before the test.
Procedure
• A 7-mL blood sample is drawn in a red-top collection tube.
• Gloves are worn throughout the procedure.
Posttest
• Apply pressure at venipuncture site. Apply dressing, periodically assessing for continued bleeding.
• Label the specimen and transport it to the laboratory.
• Report abnormal findings to the primary care provider.
Clinical Alerts
• CoQ10 is best absorbed when taken with a balanced meal.
• Providers should investigate CoQ10 benefits and side effects prior to considering
its use with patients.
Coenzyme Q10 (CoQ10) is an enzyme essential to mitochondrial ATP generation
and antioxidant function in lipid and mitochondrial membranes. According to the
American Association of Clinical Endocrinologists (2003), it has been found to have
beneficial effects for mitochondrial disorders, congestive heart failure (CHF), and
ischemia-reperfusion injury. In cases of insufficient CoQ10, electron transfer activity
of the mitochondria decreases. This results in an energy production inadequate
for cell operation. This can be especially stressful for tissues with very high energy
demand such as the heart muscle.
The role of CoQ10 in myopathy associated with statin use is also being studied.
Statins have been shown to create a CoQ10 deficiency, especially in the elderly,
since the enzyme typically decreases with age and in those with congestive heart failure.
The use of CoQ10 supplementation for statin-associated myopathy is starting to
gain support, since dietary sources of the enzyme are insufficient. Prophylactic therapy
may be considered with initiation of statin therapy. It may also be considered for
use with patients complaining of statin-associated myalgias who do not have laboratory
evidence of myositis or rhabdomyolysis, such as elevated creatine kinase levels.
ـــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــ
Normal Values
Therapeutic range for cardiovascular disease >2.5 mg/L
ـــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــ
Possible Meanings of Abnormal Values
Decreased
CoQ10 deficiency
ــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــــ
Interventions/Implications
Pretest
• Explain to the patient the purpose of the test and the need for a blood sample to be drawn.
• No fasting is required before the test.
Procedure
• A 7-mL blood sample is drawn in a red-top collection tube.
• Gloves are worn throughout the procedure.
Posttest
• Apply pressure at venipuncture site. Apply dressing, periodically assessing for continued bleeding.
• Label the specimen and transport it to the laboratory.
• Report abnormal findings to the primary care provider.
Clinical Alerts
• CoQ10 is best absorbed when taken with a balanced meal.
• Providers should investigate CoQ10 benefits and side effects prior to considering
its use with patients.
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