Anti-SS-A (Ro) and Anti-SS-B (La) Antibody
Test Description
Anti-Ss-A (Ro) and anti-SS-B (La) are autoantibodies formed against ribonucleic
acid (RNA) protein particles in the body. These antibodies are most often seen in
Sjögren’s syndrome, a disorder with symptoms similar to those of connective tissue
disorders such as rheumatoid arthritis, systemic lupus erythematosus (SLE), or
scleroderma. The syndrome is characterized by decreased secretion and eventual
destruction of the exocrine glands, resulting in dryness of the mucosa and conjunctiva.
The test is used in the differential diagnosis of Sjögren’s syndrome, SLE,
and mixed connective tissue disease.
Normal Values
Ro: Negative
La: Negative
Possible Meanings of Abnormal Values
Positive
ANA-negative lupus
Neonatal lupus
Scleroderma
Sjögren’s syndrome
Interventions/Implications
Pretest
• Explain to the patient the purpose of the test and the need for a blood sample to be
drawn.
• No fasting is required before the test.
Procedure
• A 7-mL blood sample is drawn in a red-top collection tube.
• Gloves are worn throughout the procedure.
Posttest
• Apply pressure at venipuncture site. Apply dressing, periodically assessing for continued
bleeding.
• Label the specimen and transport it to the laboratory.
• Report abnormal findings to the primary care provider.
Cinical alert
• Infection at the venipuncture site may occur in immunocompromised individuals.
Teach the patient to monitor the site and to report the occurrence of infection,
including drainage, redness, warmth, edema, pain at the site, or fever.
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