Angiotensin-Converting Enzyme

Test Description

Angiotensin-converting enzyme (ACE) is an enzyme found primarily in the epithelial

cells of the lungs and in smaller concentrations in the blood vessels and kidneys.

This enzyme is responsible for stimulating the conversion of angiotensin I to

angiotensin II, a vasoconstricting agent, which, in turn, stimulates the adrenal cortex

to produce aldosterone.

There has been found a high correlation between high ACE levels and patients

with active sarcoidosis. Thus, this test is used in the diagnosis of sarcoidosis, as

well as to monitor patient response to therapy for the disease. It can also be used

in the diagnosis of Gaucher’s disease.

Normal Values

<40 mcg/L (<670 nkat/L SI units)

Possible Meanings of Abnormal Values

Increased

Diabetes mellitus

Gaucher’s disease

Hyperthyroidism

Leprosy

Liver disease

Sarcoidosis

Contributing Factors to Abnormal Values

• Drugs that may decrease ACE levels: ACE-inhibitors, prednisone.

Interventions/Implications

Pretest

• Explain to the patient the purpose of the test and the need for a blood sample to be drawn.

• No fasting is required before the test.

Procedure

• A 7-mL blood sample is drawn in a red-top collection tube.

• Gloves are worn throughout the procedure.

Post test

• Apply pressure at venipuncture site. Apply dressing, periodically assessing for continued

  bleeding.

• Label the specimen and transport it to the laboratory.

• Report abnormal findings to the primary care provider.