ALDOLASE
Aldolase
Test Description
Aldolase is a glycolytic enzyme that is present in all body cells. The highest concentrations
of aldolase are found in the cells of skeletal muscles, the heart, and liver
tissue, although the test is considered most specific for muscle tissue destruction.
When damage to muscle tissue occurs, cells are destroyed, resulting in the release
of aldolase into the blood. Thus, testing for aldolase is useful in monitoring the
progress of muscle damage in such disorders as muscular dystrophy.
Normal Values
Adult: 0–7 U/L (0–117 nkat/L SI units)
Child: Two times adult norms
Newborn: Four times adult norms
Possible Meanings of Abnormal Values
Increased Decreased
Burns Late muscular dystrophy
Dermatomyositis
Gangrene
Hepatitis
Liver cancer
Muscle inflammation
Muscle necrosis
Muscle trauma
Myocardial infarction
Myositis
Polymyositis
Progressive muscular dystrophy
Pulmonary infarction
Contributing Factors to Abnormal Values
• Hemolysis of the blood sample falsely increases the test results.
• Recent minor trauma, including intramuscular injections, may increase the aldolase
level.
• Drugs that may increase aldolase levels: corticotropin, cortisone acetate, hepatotoxic
drugs.
• Drugs that may decrease aldolase levels: phenothiazines.
Interventions/Implications
Pretest
• Explain to the patient the purpose of the test and the need for a blood sample to be drawn.
• Although fasting is not required before the test, some institutions require a short fasting
period to improve the accuracy of the test results.
Procedure
• A 5-mL blood sample is drawn in a collection tube containing a silicone gel.
• Gloves are worn throughout the procedure.
Posttest
• Apply pressure at venipuncture site. Apply dressing, periodically assessing for continued
bleeding.
• Label the specimen and transport it to the laboratory.
• Report abnormal findings to the primary care provider.
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